Lean and Six Sigma are complementary methodologies with accompanied tools that many companies are combining and using in most aspects of business. Lean and Six Sigma were derived from the Manufacturing and Quality fields. Lean methods focus on the ability to identify waste, reduce it, and aggressively go for the elimination of non-value added activities and improve response to that business’ customer base. Six Sigma seeks to improve the quality of process output by identifying and removing the causes of defect and minimizing process variability. This article compares and contrasts Systems Engineering (SE) to Lean Six Sigma. This is more than Lean SE by the addition of Six Sigma. The Author’s main conclusions are the following: (1) Systems Engineering efforts can improve by using most of the Lean Six Sigma tools. (2) Systems Engineers can gain synergy by understanding the differences in terms, and tool usage. This article explains the method of literature search research for comparative analysis. Further research should attempt to validate, improve, and expand and the articles assertions.