Today’s technical challenges require government and industry to solve ever more complex problems, at an increased pace, and at a lower lifecycle cost. Maintaining a competitive edge along each of the performance, lifecycle cost, and schedule (time-to-market) axes is essential to competitive viability. Systems of systems are emerging in many of our competitive domains; these address problem complexity while introducing Systems Engineering complexity. Systems Engineering has been struggling to cope with these increasingly complex systems, which often times also require a broader scope of subject matter expertise. The synergistic combination of three product development paradigms: Model-Based Systems Engineering (MBSE), Multidisciplinary Design Analysis and Optimization (MDAO), and Product Line Architecture (PLA) — can change all of that. MBSE is a development paradigm that uses models to specify requirements, functionality, performance, and/or design for analysis and/or implementation purposes. MDAO is a way of computationally tying together a multidisciplinary set of design, modeling, simulation, and analysis models to understand how variance in system parameters affects key technical measures. PLA focuses on architecting families of products for pre-planned reuse of features common to members of the product families, and on applying feature variability with decreased costs and time. This presentation will describe an approach to integrating these three development paradigms to enable more reuse than is currently possible, provide a means for capturing and leveraging subject matter expertise, and to streamline development by reducing development cost and risk.